Sermorelin (GRF 1-29)
Sermorelin (GRF 1-29) Sermorelin Peptides Online
Molecular formula: C149H246N44O42S
Molar Mass: 3357.96
CAS number: 86168-78-7
PubChem: CID 16133753
Synonyms: Sermorelin acetate hydrate, GRF 1-29 NH2
Sermorelin Acetate, also known as GRF 1-29, is a Growth Hormone Releasing Hormone (GHRH) produced by the brain that stimulates the production and release of Growth Hormone (GH). Sermorelin Acetate was first developed in the 70s, which is thought to be the shortest fully functional fragment of GHRH and has been used as a test for Growth Hormone secretion. It is often used extensively in Anti-aging Therapy along with Testosterone in men. Sermorelin Acetate affects a more primary source of failure in the GH neuroendocrine axis, has more physiological activity, and its use for adult hormone deficiency is not restricted. Compared to human Growth Hormone (hGH), Sermorelin Acetate is a growth hormone secretagogue, which means that it stimulates the pituitary gland to produce and secrete growth hormone. Also, Sermorelin Acetate and Modified GRF 1-29 contains 29 amino acids whereas hGH is a larger molecule containing 191 amino acids.
So, why would you never use Sermorelin? Well…there are many reasons why bodybuilders and athletes may not ever touch this peptide, but we will get into that later. Let me start off by saying Sermorelin is actually known to us by the name GRF (1-29). We touched on this in my last article when we discussed CJC 1295 and how CJC 1295 without DAC is really modified version of GRF (1-29) aptly named MOD GRF (1-29). The original GFR (1-29) is, in fact, the root of the HGH molecule and that remaining peptide containing the first 29 amino acids is actually what is responsible for stimulating pituitary response. The name Sermorelin is the prescription drug name and this alone is why it is so widely prescribed by hormone replacement therapy clinics (HRT).
Even though in bodybuilding circles we don’t hear much about Sermorelin, this doesn’t mean that this peptide does not have its uses. In fact, anti-aging and hormone replacement clinics have been prescribing it for years because it works as a clean GHRH. The problem for the bodybuilder or athlete is that it has a very short half-life of about ten (10) minutes. This becomes an unattractive feature when compared to the half-life of MOD GRF (1-29) (CJC 1295 without DAC), which comes in around 30 minutes. Despite its short window, it does bind quite effectively to the pituitary receptors. The other main down side associated with its very short half life is that it is quickly broken down by blood enzymes within minutes. This is why a GHRH peptide with a half life of 30 minutes or longer is desirable, since it will survive the blood enzyme death and allow it to circulate the body looking for hormone receptors to bind to.